Blar i forfatter "Adekoya, Olayiwola"
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Inhibition of bacterial and human zinc-metalloproteases by bisphosphonate- and catechol-containing compounds
Rahman, Fatema; Nguyen, Tra-Mi; Adekoya, Olayiwola; Campestre, Cristina; Tortorella, Paolo; Sylte, Ingebrigt; Winberg, Jan-Olof (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-23)Compounds containg catechol or bisphosphonate were tested as inhibitors of the zinc metalloproteases, thermolysin (TLN), pseudolysin (PLN) and aureolysin (ALN) which are bacterial virulence factors, and the human matrix metalloproteases MMP-9 and −14. Inhibition of virulence is a putative strategy in the development of antibacterial drugs, but the inhibitors should not interfere with human enzymes. ... -
Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A<sub>2</sub>, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines
Jantan, Ibrahim; Bukhari, Syed Nasir Abbas; Adekoya, Olayiwola; Sylte, Ingebrigt (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-09-16)Arachidonic acid metabolism leads to the generation of key lipid mediators which play a fundamental role during inflammation. The inhibition of enzymes involved in arachidonic acid metabolism has been considered as a synergistic anti-inflammatory effect with enhanced spectrum of activity. A series of 1,3-diphenyl-2-propen-1-one derivatives were investigated for anti-inflammatory related activities ... -
Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors
Sjøli, Stian; Nuti, Elisa; Camodeca, Caterina; Bilto, Irina; Rossello, Armando; Winberg, Jan-Olof; Sylte, Ingebrigt; Adekoya, Olayiwola (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11-28)Enzymes of the M4 family of zinc-metalloproteinases are virulence factors secreted from gram-positive or gram-negative bacteria, and putative drug targets in the treatment of bacterial infections. In order to have a therapeutic value such inhibitors should not interfere with endogenous zinc-metalloproteinases. In the present study we have synthesised a series of hydroxamate derivatives and validated ... -
Understanding the binding of inhibitors of matrix metalloproteinases by molecular docking, quantum mechanical calculations, molecular dynamics simulations, and a MMGBSA/MMBappl study
Singh, Tanya; Adekoya, Olayiwola; Jayaram, B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-14)Matrix metalloproteinases (MMPs) consist of a class of proteins required for normal tissue function. Their over expression is associated with many disease states and hence the interest in MMPs as drug targets. Almost all MMP inhibitors have been reported to fail in clinical trials due to lack of specificity. Zinc in the binding site of metalloproteinases performs essential biological functions ...